Our aim is to investigate the molecular mechanisms of intracellular trafficking pathways and membrane recruitment in order to better understand the fundamental biology underlying human disease.
Intracellular protein and lipid localization is critical for normal cellular function. Genetic disruptions in the pathways that control their targeting are often implicated in neurological disorders and cancer. We are interested in understanding the molecular mechanisms that underlie trafficking and membrane protein-associated genetic disease. To investigate this, we use a variety of techniques in both mammalian cells and the budding yeast S. cerevisiae that range from live-cell imaging and biochemical characterization to systems level genomics. These approaches afford us the ability to address research questions with both scope and depth. We are located in beautiful Vancouver, British Columbia at the Centre for Molecular Medicine and Therapeutics, a partner of BC Children's Hospital Research Institute. Research groups at BC Children's Hospital range from molecular biology labs to disease gene discovery programs, resulting in a dynamic environment that fosters collaborative science.
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